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CST), CHAC1 (ab76386, Abcam), Vinculin (MAB3574, Sigma), FASN (ab22759, Abcam), SCD1 (2438, CST), total OXPHOS (ab110413, Abcam), NOTCH1 (3608, CST), NOTCH2 (5732, CST), HES1 (sc-166410, Santa Cruz Biotechnology), SPP1 (AF808, R&D Systems), and -tubulin (2146

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rapa (Br), and B

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Mechanisms of iron accumulation during ferroptosis Iron is an essential component of biological systems and exists in two biologically relevant oxidation states, ferric iron (Fe 3+ ) and ferrous iron (Fe 2+ ), and functions as a cofactor for several proteins and enzymes that can readily undergo redox cycling

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77,78,79 For example, Golodirsen, an ASO drug targeting the human Duchenne muscular dystrophy (DMD) gene, was introduced in the USA in 2019 by Sarepta Therapeutics to treat DMD patients with confirmed mutations amenable to exon 53 skipping

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Expression of deoxyribonucleic acid repair enzymes during spermatogenesis in mice

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